Biochemistry 2

Masayoshi MAESHIMA Professor

Department: School of Agricultural Sciences / Graduate School of Bioagricultural Sciences

Course Overview

Course Overview

All organisms take foods and use them to get elements for their own components, such as proteins, and energy through various metabolisms including glycolysis, citric acid cycle, and energy-yielding metabolism.

The lecture provides basic information on chemical characteristics of the enzyme reactions, the detailed reactions of the glycolysis and citric acid cycle, biochemical regulation, and their physiological significance. Also this course examines how cells transduce energy obtained from glucose to ATP production through oxidative phosphorylation.

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Syllabus

Course Aims

Through the lecture, students will be able to:

• understand the chemical logic and biochemical reactions of sugar metabolism and oxidative phosphorylation
• define physicochemical logic of bioenergetics
• understand general properties of enzymes
• describe and calculate the parameters of enzyme reactions

Keywords

Metabolism, glycolysis, citric acid cycle, urea cycle, enzyme kinetics, oxidative phosphorylation, ATP synthesis

Textbook

Lehninger Princeples of Biochemistry, Sixth edition (Fifth edition for Japanese translation)

References

The instructors will pass out handouts in class. Other reading materials will be introduced by the instructors

Related Classes

Biochemistry 1, Basic chemistry II

Course Schedule

Part1 Instructor: MAESHIMA
1	General introduction
2	Cell compartments and their biochemical roles
3	Biochemical methods to analyze proteins (introduction for genomes, subcellular fractionation, protein purification, and functional analysis)
4	Enzyme kinetics as an approach to understanding metabolism (Enzyme kinetics, Michaelis-Menten equation, and Enzyme inhibitors)
Part2 Instructor: HORIO
5	Glycolysis
6	Regulation of metabolic pathway
7	Pentose phosphate pathway of glucose oxidation
8	Citric acid cycle
9	Oxidation of fatty acid
10	Amino acid oxidation and urea cycle
Part3 Instructor: MAESHIMA
11	Enzyme inhibitors and kinetic tests
12	Coenzymes and cofactors
13	Bioenergetics: ATP and high-energy phosphate compounds
14	Oxidative phosphorylation
15	Energy efficiency of ATP synthesis

Grading

Attendance (20%), final exam (80%)

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